AB0457 IMPROVED PREGNANCY OUTCOMES IN WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS: A RETROSPECTIVE STUDY OF PREGNANCIES FROM A SINGLE CENTER IN DENMARK FROM 2010-2020 COMPARED WITH THE PERIOD 1990-2010

Background Over the past decades, approach to follow and treat pregnant SLE patients has changed. Today it is recommended that are monitored closely in a multi-professional team throughout pregnancy (1). The importance of low disease activity before continued treatment during been established (2). Even though many improvements management pregnancies made, there still high risk adverse outcome (APO). Objectives We aimed evaluate APO Danish cohort followed from 2010-2020 compare results with previous study same referral area 1990-2010 (3). Methods This retrospective used local patient registry identify at Department Rheumatology, Aarhus University Hospital, Denmark January 2010 October 2020. All were regularly fulfilled least four 1997 American College Rheumatology (ACR) criteria for classification. Data included demographic, clinical, laboratory data. Demographics ethnicity, smoking habits, body mass index (BMI), concomitant APS (recognized pregnancy). compared data (1990-2010) department. Results In total, 66 registered 41 women. occurred 65 % pregnancies. Forty-seven resulted live birth, while 15 ended miscarriage. Compared cohort, reduction preterm deliveries (7.58 vs. 17.9 %), acute caesarean (6.1 15.5 higher average birth weight (3045 g 2870 g) found (Table 1). Further, we observed more births per year (Figure A change was found, i.e., significantly treated hydroxychloroquine (73 %) (6 %). Figure 1. Pregnancy outcome. Average number period Table Maternal fetal/neonatal outcomes our population (2010-2020) Hospital (1990-2010). n=84 n=66 p-value Pre-eclampsia/eclampsia, n (%) 7 (8.3) 8 (12.1) 0.59 HELLP syndrome, 4 (4.8) 0 - Gestational hypertension, 20 (23.8) 9 (13.6) 0.05 Preterm (<37 th gestational week), (17.9) 5 (7.58) 0.07 Acute delivery, 13 (15.5) (6.1) Elective 11 (13.1) Total 24 (28.6) 12 (18.2) fetal loss, 22 (26.2) 19 (28.8) 0.72 Spontaneous abortion <22 weeks, 18 (21.4) (22.7) 0.85 Therapeutic 3 (3.6) 0.47 Still 1 (1.2) Fetal death after 2 (2.4) Birth weight, mean ± SD (SD,NA) 3045 611 IUGR 10 (11.9) NA SGA (18.18) Congenital heart block, Neonatal Lupus Syndrome, Conclusion Improvements frequency 1990-2010. However, even specialized follows women SLE, carries APO. References [1]Andreoli L et al. EULAR recommendations women’s health family planning, assisted reproduction, menopause systemic lupus erythematosus and/or antiphospholipid syndrome. Ann Rheum Dis. 2017;76(3):476–85. [2]Lateef A, Petri M. Management erythematosus. Vol. 8, Nature Reviews Rheumatology. Publishing Group; 2012. p. 710–8. [3]Jakobsen IM foetal patients: an incident stable Scand J Rheumatol. 2015;44(5):377–84. Disclosure Interests None declared